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330 BCE
320 BCE
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280 BCE
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80 BCE
329 BCE - 327 BCE: Alexander conquers Bactria and Sogdiana.
327 BCE: Alexander the Great marries the Bactrian girl Roxanne.
293 BCE: Antiochos is appointed vice-king of the Upper-Satrapies by his father Seleucus I Nicator.
280 BCE: Incursion of northern nomads (Sakas) on Seleucid territories.
250 BCE: Former satrap Diodotos rebels against Seleucid king Antiochos I, creating the Greco-Bactrian kingdom.
230 BCE: Diodotos II is overthrown by Euthydemos. Beginning of the Euthydemid dynasty.
208 BCE - 206 BCE: Siege of Bactra by Antiochos III.
200 BCE - 100 BCE: Scythians tribes migrate into Bactria, Sogdiana and Arachosia.
180 BCE - 80 BCE: Period of Indo-Greek rule in the Gandhara region.
145 BCE: Murder of Eucratides by his son. Weakening of the Greco-Bactrian kingdom.
145 BCE: Eucratidia is taken by the Sakas.
139 BCE: Eucratidia is looted to the ground by the Yuezhei.
130 BCE: The Yuezhei take control of Bactria.