1205 CE - 1215 CE: Reign of Michael I Komnenos Doukas in Epirus.

1205 CE - 1479 CE: Despotate of Epirus.

1215 CE - 1230 CE: Reign of Theodore I Komnenos Doukas in Epirus.

1217 CE: Theodore I Komnenos Doukas of Epirus captures Peter of Courtenay, the Latin Emperor.

1224 CE: Theodore I Komnenos Doukas of Epirus recaptures Thessalonica from the Latins.

1227 CE: Theodore I Komnenos Doukas crowned the Emperor of Thessalonica in Ohrid.

1230 CE - 1241 CE: Reign of Manuel Komnenos Doukas in Thessalonica (1230-1237 CE) and Thessaly (1230-1241 CE).

1230 CE - 1267 CE: Reign of Michael II Komnenos Doukas, Despot of Epirus.

1230 CE: Battle of Klokotnitsa, in which the Bulgarian army under Tsar Ivan Asen II defeated Theodore Komennos Doukas, Despot of Epirus.

1237 CE - 1244 CE: Reign of John Komnenos Doukas in Thessalonica.

1242 CE: The Empire of Thessalonica is forced to submit as a despotate to the Empire of Nicaea.

1244 CE - 1246 CE: Reign of Demetrios Komnenos Doukas in Thessalonica.

1246 CE: The Empire of Nicaea conquers Thessalonica.

1257 CE: Manfred of Sicily invades the Despotate of Epirus and conquers Durazzo, Corfu, Valona, Kanina, and Berat.

1259 CE: Battle of Pelagonia: Byzantine forces defeat the combined armies of the Principality of Achaea and Manfred of Sicily. Epirote forces withdraw before the battle.

1264 CE: Peace treaty between the Byzantine Empire and the Despotate of Epirus.

1267 CE - 1297 CE: Reign of Nikephoros I Komnenos Doukas, Despot of Epirus.

1297 CE - 1318 CE: Reign of Thomas Komnenos Doukas, Despot of Epirus.

1318 CE: Thomas Komnenos Doukas, Despot of Epirus, is murdered by his nephew, Count Nicholas Orsini of Cephalonia.

1318 CE - 1323 CE: Reign of Nicholas Orsini, Despot of Epirus.

1318 CE: The city of Ioannina joins the Byzantine Empire.

1323 CE - 1335 CE: Reign of John II Orsini, Despot of Epirus.

1325 CE: John II Orsini, Despot of Epirus, is dethroned as Count of Cephalonia.

1333 CE: Brief occupation of land in Thessaly by the Despotate of Epirus.

1335 CE - 1340 CE: Reign of Nikephoros II Orsini, Despot of Epirus.

1338 CE: Anna, widow of John II Orsini, signs over the Despotate of Epirus to the Byzantine Empire.

1340 CE: Byzantine forces defeat the Epirote rebels under Nikephoros II Orsini, reincorporating the territory into the Byzantine Empire.

1348 CE: Serbian forces under Stefan Dusan conquer Epirus.

1356 CE - 1359 CE: Second reign of Nikephoros II Orsini, Despot of Epirus.

1359 CE - 1367 CE: Reign of Symeon Uros over Ioannina.

1367 CE - 1384 CE: Reign of Thomas Preljubovic in Ioannina.

1385 CE - 1411 CE: Reign of Esau Buondelmonti in Ioannina.

1399 CE: Esau Buondelmonti, Despot of Ioannina, is captured by Albanians.

1400 CE - 1408 CE: Carlo I Tocco, Count of Cephalonia, conquers Akarnania and Aitolia from the Albanians.

1411 CE: Carlo I Tocco is proclaimed the lord of Ioannina.

1412 CE: Battle of Kranea: Albanian forces defeat Carlo I Tocco, Count of Cephalonia.

1415 CE: Manuel II Palaiologos grants the title of despot of Epirus to Carlo I Tocco, Count of Cephalonia.

1416 CE: Carlo I Tocco conquers the city of Arta, reuniting the Despotate of Epirus.

1421 CE - 1426 CE: Carlo I Tocco, Despot of Epirus, attempts to conquer the Principality of Achaea, but is defeated by Byzantine forces.

1429 CE - 1448 CE: Reign of Carlo II Tocco in Epirus.

1430 CE: Ioannina surrenders to the Ottoman Empire.

1448 CE - 1479 CE: Reign of Leonardo III Tocco in Epirus.

1449 CE: Arta is conquered by the Ottoman Empire.

1479 CE: The Ottoman Empire conquers the remaining territory of the Despotate of Epirus: Vonitsa, Cephalonia, Ithaka, Zante, and Lefkada.