1432 CE: Mehmed II is born.

1437 CE: Mehmed II is appointed governor of Amasya.

1444 CE: Mehmed II inherits the throne after Sultan Murad II abdicates.

1444 CE: Murad II resumes defeats Crusader forces at the Battle of Varna.

1451 CE - 1481 CE: Mehmed II rules as the Sultan.

1451 CE: Mehmed II succeeds Murad as sultan following his death.

1452 CE: Construction of fortress Rumelihisari is complete.

1453 CE: Siege of Constantinople begins.

1453 CE: Ottoman Sultan Mehmed II sacks Constantinople.

1454 CE - 1459 CE: Ottoman campaigns in Serbia.

1456 CE: Ottoman forces besiege Trebizond.

1456 CE: Mehmed II is dealt his first major defeat at the Siege of Belgrade.

1461 CE: Ottoman forces under Sultan Mehmed II capture Trebizond, ending the Empire of Trebizond.

1461 CE: David Megas Komnenos, the last Emperor of Trebizond, is deposed by the Ottomans.

1462 CE: Mehmed II defeats Vlad III in the Battle of Târgoviște.

1463 CE - 1479 CE: The Ottomans fight a long war against the Venetians over their possessions in the Aegean.

1463 CE - 1470 CE: The Mosque of the Conqueror is constructed in Constantinople.

1465 CE: Mehmed II oversees construction of Topkapi Palace, the new seat of his empire.

1481 CE: Mehmed II falls ill during a military expedition and subsequently dies, leading to the succession of his eldest son Bayezid II to the throne.