1621 CE - 1622 CE: The pilgrims establish the Plymouth Colony with the help of Native Americans who teach them how to survive and flourish.

1622 CE: New Hampshire Colony founded.

1628 CE - 1630 CE: Establishment of the Massachusetts Bay Colony led by Puritans seeking to evangelize the native population of North America.

1636 CE - 1638 CE: The Pequot War; John Winthrop presides over policy concerning the massacre and enslavement of the Pequot tribe.

1636 CE: Roger Williams establishes the colony of Providence Plantation (later known as Providence, Rhode Island).

1636 CE: Connecticut Colony founded.

1638 CE: Anne Hutchinson banished from Massachusetts Bay Colony; founds Portsmouth, Rhode Island.

1638 CE: New Haven Colony founded.

1675 CE - 1678 CE: King Philip's War in which thousands are killed as the Native Americans try to defend their land and way of life from increasing European colonization of the Americas.

1691 CE: Plymouth Colony is absorbed into the Massachusetts Bay Colony under the latter's new charter.