1620 CE - 1621 CE: Half of the pilgrims die during the winter of 1620-1621 from disease, exposure, and malnutrition.

1620 CE: The Mayflower lands in the region of modern-day Massachusetts, North America, bringing the pilgrims to the New World.

1620 CE: The Mayflower Compact is signed by the pilgrims establishing democratic government of the Plymouth Colony.

1621 CE - 1622 CE: The pilgrims establish the Plymouth Colony with the help of Native Americans who teach them how to survive and flourish.

1622 CE: Captain Myles Standish disrupts relations with the Native Americans by executing two for no reason; trade relationships fall off.

1628 CE - 1630 CE: Establishment of the Massachusetts Bay Colony led by Puritans seeking to evangelize the native population of North America.

1675 CE - 1678 CE: King Philip's War in which thousands are killed as the Native Americans try to defend their land and way of life from increasing European colonization of the Americas.

1678 CE - 1691 CE: Native Americans are sold into slavery or moved onto reservations as more European colonists arrive in North America.

1691 CE: Plymouth Colony is absorbed into the Massachusetts Bay Colony under the latter's new charter.