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240 CE
250 CE
260 CE
270 CE
240 CE - 270 CE: Reign of Shapur I, who first brought the Sassanian empire to its peak.
260 CE: Shapur I captures the Roman emperor Valerian at Edessa.
262 CE - 266 CE: Odaenathus expels Persian garrisons and restores Syria and Armenia to the Roman Empire. Odaenathus invades Mesopotamia, and inflicts two defeats upon Shapur I, which ends with the sack of Ctesiphon.
270 CE - 273 CE: Reign of Hormizd I, son of Shapur I.